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A study reported that histological abnormalities were first observed in the esophageal tissues of rats with reflux esophagitis, and found that the recruitment of inflammatory cells and the expression of inflammatory chemokines within the esophageal mucosal epithelium were significantly earlier than the macroscopically or microscopically visible esophageal epithelial cell injury (66)

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Data from the World Health Organization (WHO) shows that obesity has almost tripled globally since 1975, impacting over 650 million adults and 340 million children and adolescents in 2016

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